1-(adaMantan-1-yl)ethanaMine hydrochloride
Rimantadine
CAS: 13392-28-4
Molecular Formula: C12H21N
1-(adaMantan-1-yl)ethanaMine hydrochloride - Names and Identifiers
| Name | Rimantadine |
| Synonyms | 1-Adaman RiMantidine Rimantadine 1-Rimantadine 1-Adamantanethylamine RiMantadine (FluMadine) 1-(1-Adamantyl)-ethylamine 1-Adamantan-1-ylethylamine 1-(AdaMantan-1-yl)ethanaMine 1-(adaMantan-1-yl)ethanaMine hydrochloride 2-(tricyclo[3.3.1.1~3,7~]dec-1-yl)ethanamine 1-(tricyclo[3.3.1.1~3,7~]dec-1-yl)ethanamine |
| CAS | 13392-28-4 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C12H21N/c13-2-1-12-6-9-3-10(7-12)5-11(4-9)8-12/h9-11H,1-8,13H2 |
1-(adaMantan-1-yl)ethanaMine hydrochloride - Physico-chemical Properties
| Molecular Formula | C12H21N |
| Molar Mass | 179.3 |
| Density | 1.033 |
| Boling Point | 248°C |
| Flash Point | 99°C |
| Vapor Presure | 0.0249mmHg at 25°C |
| pKa | 11.17±0.29(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.539 |
| Use | Mainly used for the manufacture of various types of levofloxacin capsules, tablets and other antibacterial preparations |
1-(adaMantan-1-yl)ethanaMine hydrochloride - Risk and Safety
| Hazard Class | IRRITANT |
1-(adaMantan-1-yl)ethanaMine hydrochloride - Upstream Downstream Industry
1-(adaMantan-1-yl)ethanaMine hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.577 ml | 27.886 ml | 55.772 ml |
| 5 mM | 1.115 ml | 5.577 ml | 11.154 ml |
| 10 mM | 0.558 ml | 2.789 ml | 5.577 ml |
| 5 mM | 0.112 ml | 0.558 ml | 1.115 ml |
Last Update：2024-01-02 23:10:35
1-(adaMantan-1-yl)ethanaMine hydrochloride - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| levofloxacin hydrochloride capsule | [pharmacological action] this product has broad-spectrum antibacterial effect, strong antibacterial effect, and is against most enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Haemophilus influenzae, Legionella pneumophila, Neisseria gonorrhoeae and other gram-negative bacteria have strong antibacterial activity. It also has antibacterial effects on Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and other gram-positive bacteria, Mycoplasma pneumoniae, Chlamydia pneumoniae, but has poor effects on anaerobic bacteria and Enterococcus. This product is a levoxil of ofloxacin, and its antibacterial activity in vitro is about twice that of ofloxacin. Its mechanism of action is to inhibit the activity of bacterial DNA gyrase and prevent the synthesis and replication of bacterial DNA, resulting in bacterial death. [Contraindications] It is forbidden for patients who are allergic to this product and fluoroquinolones. |
| indications | this product is suitable for the following mild, moderate and severe respiratory infections caused by sensitive bacteria: acute bronchitis, chronic bronchitis, acute attack of chronic bronchitis, diffuse bronchiolitis, bronchiectasis complicated infection, pneumonia, pharyngitis, tonsillitis (peritonsillar abscess). Urinary system infection: pyelonephritis, complicated urinary tract infection, etc. Reproductive system infection: prostatitis, epididymitis, uterine cavity infection, uterine adnexitis, pelvic inflammatory disease (metronidazole can be used when anaerobic infection is suspected). Skin and soft tissue infections: infectious impetigo, cellulitis, lymphangiitis, subcutaneous abscess, perianal abscess, etc. Intestinal infection: bacillary dysentery, infectious enteritis, salmonella enteritis, typhoid fever and paratyphoid fever, etc. Other infections: trauma, burns and post-operative wound infections, abdominal infections (metronidazole if necessary), mastitis, cholecystitis, cholangitis, bone and joint infections, and ENT infections. |
| drug interaction | 1. levofloxacin hydrochloride cannot be used in the same infusion tube with solutions of polyvalent metal ions such as magnesium and calcium. 2. Avoid using theophylline at the same time. If it needs to be used at the same time, the blood concentration of theophylline should be monitored to adjust the dose. 3. When used simultaneously with warfarin or its derivatives, prothrombin time or other coagulation tests should be monitored. 4. Simultaneous application with non-steroidal anti-inflammatory drugs may cause convulsions. 5. Simultaneous use with oral hypoglycemic drugs may cause hypoglycemia. Therefore, attention should be paid to monitoring the blood concentration during the medication process. Once hypoglycemia occurs, this product should be stopped immediately and given appropriate treatment. |
| usage and dosage | oral administration. Common dosage for adults: 1. Bronchial infection and pulmonary infection: 0.2g(2 tablets) once, twice a day, or 0.1g(1 tablet) once, 3 times a day, for 7-14 days. 2. Acute simple lower urinary tract infection: 0.1g(1 capsule) once, twice a day, with a course of treatment of 5-7 days; Complicated urinary tract infection: 0.2g(2 capsules) once, twice a day, or 0.1g(1 capsule) once, 3 times a day, with a course of treatment of 10-14 days. 3. Bacterial prostatitis: 0.2g(2 tablets) once, twice a day, the course of treatment is 6 weeks. The common dosage for adults is 0.3~0.4g(3~4 tablets) a day, and it is taken in 2~3 times. For those with severe infection or poor susceptibility to infected pathogens, such as Pseudomonas aeruginosa and other Pseudomonas bacteria The therapeutic dose for infection can also be increased to 0.6g(6 tablets) a day, and it can be taken in 3 times. |
| biological activity | Rimantadine is an anti-influenza virus drug that acts on T. brucei with an IC50 of 7 μM. |
| use | mainly used to manufacture various kinds of levofloxacin capsules, tablets and other antibacterial preparations |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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Raw Materials for 1-(adaMantan-1-yl)ethanaMine hydrochloride